Endocrine Abstracts

Congenital adrenal hyperplasia (CAH), caused by lack of 21-hydroxylase, impairs cortisol secretion, which increases ACTH release that results in hyperplasia of adrenal glands and increased secretion of adrenal androgens. Elevated androgen concentration leads to increased skeletal maturation, early pubertal development and diminished pubertal growth. Treatment with glucocorticoids averts early puberty but may abruptly slow down growth. The effect of exogenous glucocorticoids on...

Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder caused by deficiency of 21-hydroxylase (CYP21), which inhibits adrenal synthesis of cortisol and aldosterone. The reduced cortisol synthesis leads to increased ACTH secretion, which results in adrenal gland hyperplasia, accumulation of steroid precursors and excessive adrenal androgen production, causing pseudoprecocious puberty. The study aimed at determining variance in two SNPs, I172N and V281L, of CYP2...